25 results
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial
- Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Célia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. McDonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
-
- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 6 / December 2023
- Published online by Cambridge University Press:
- 14 July 2023, pp. 533-541
- Print publication:
- December 2023
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed.
AimsTo assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au.
MethodThis phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4.
ResultsThe final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h.
ConclusionsAdequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible.
Vitamin D status of children with paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS)
- Angeline Darren, Meissa Osman, Kavitha Masilamani, Syed Habib Ali, Hari Krishnan Kanthimathinathan, Ashish Chikermane, Eslam Al-Abadi, Steven B. Welch, Scott Hackett, Barnaby R. Scholefield, Suma Uday, Deepthi Jyothish
-
- Journal:
- British Journal of Nutrition / Volume 127 / Issue 6 / 28 March 2022
- Published online by Cambridge University Press:
- 12 May 2021, pp. 896-903
- Print publication:
- 28 March 2022
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Coronavirus disease 2019 (COVID-19) has caused mild illness in children, until the emergence of the novel hyperinflammatory condition paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS). PIMS-TS is thought to be a post-SARS-CoV-2 immune dysregulation with excessive inflammatory cytokine release. We studied 25 hydroxyvitamin D (25OHD) concentrations in children with PIMS-TS, admitted to a tertiary paediatric hospital in the UK, due to its postulated role in cytokine regulation and immune response. Eighteen children (median (range) age 8·9 (0·3-14·6) years, male = 10) met the case definition. The majority were of Black, Asian and Minority Ethnic (BAME) origin (89 %, 16/18). Positive SARS-CoV-2 IgG antibodies were present in 94 % (17/18) and RNA by PCR in 6 % (1/18). Seventy-eight percentage of the cohort were vitamin D deficient (< 30 nmol/l). The mean 25OHD concentration was significantly lower when compared with the population mean from the 2015/16 National Diet and Nutrition Survey (children aged 4–10 years) (24 v. 54 nmol/l (95 % CI −38·6, −19·7); P < 0·001). The paediatric intensive care unit (PICU) group had lower mean 25OHD concentrations compared with the non-PICU group, but this was not statistically significant (19·5 v. 31·9 nmol/l; P = 0·11). The higher susceptibility of BAME children to PIMS-TS and also vitamin D deficiency merits contemplation. Whilst any link between vitamin D deficiency and the severity of COVID-19 and related conditions including PIMS-TS requires further evidence, public health measures to improve vitamin D status of the UK BAME population have been long overdue.
The role of loneliness in the development of depressive symptoms among partnered dementia caregivers: Evidence from the English Longitudinal Study of Aging
- J. P. Saadi, E. Carr, M. Fleischmann, E. Murray, J. Head, A. Steptoe, R. A. Hackett, B. Xue, D. Cadar
-
- Journal:
- European Psychiatry / Volume 64 / Issue 1 / 2021
- Published online by Cambridge University Press:
- 26 March 2021, e28
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
Depressive symptoms are highly prevalent among partnered dementia caregivers, but the mechanisms are unclear. This study examined the mediating role of loneliness in the association between dementia and other types of care on subsequent depressive symptoms.
MethodsProspective data from partnered caregivers were drawn from the English Longitudinal Study of Aging. The sample consisted of 4,672 partnered adults aged 50–70 living in England and Wales, followed up between 2006–2007 and 2014–2015. Caregiving was assessed across waves 3 (2006–2007), 4 (2008–2009), and 5 (2010–2011), loneliness at wave 6 (2012–2013), and subsequent depressive symptoms at wave 7 (2014–15). Multivariable logistic regression models were used to assess the association between caregiving for dementia and depressive symptoms compared to caregiving for other illnesses (e.g., diabetes, coronary heart disease (CHD), cancer, and stroke). Binary mediation analysis was used to estimate the indirect effects of caregiving on depressive symptoms via loneliness.
ResultsCare for a partner with dementia was associated with higher odds of depressive symptoms at follow-up compared to those not caring for a partner at all (odds ratio [OR] = 2.6, 95% confidence intervals [CI]: 1.4, 5.1). This association was partially mediated by loneliness (34%). Care for a partner with other conditions was also associated with higher odds of depressive symptoms compared to non-caregiving partners (OR = 1.7, 95% CI: 1.2, 2.5), but there was no evidence of an indirect pathway via loneliness.
ConclusionLoneliness represents an important contributor to the relationship between dementia caregiving and subsequent depressive symptoms; therefore, interventions to reduce loneliness among partnered dementia caregivers should be considered.
Relating active optical sensor measurements to barley yield
- R. Hackett
-
- Journal:
- Advances in Animal Biosciences / Volume 8 / Issue 2 / July 2017
- Published online by Cambridge University Press:
- 01 June 2017, pp. 162-166
- Print publication:
- July 2017
-
- Article
- Export citation
-
The objective of this work was to determine the most appropriate growth stage to make reflectance measurements that would indicate yield in high yielding winter barley crops. The results indicated that where different rates of fertiliser N were applied, at the same crop growth stages, the best relationship between vegetation indices, calculated on the basis of reflectance measurements, and grain yield were found to occur from booting to early grain fill. Where the timing of fertiliser N inputs was different, for a given level of fertiliser N addition, poor correlations between vegetation indices and grain yield during the stem elongation phase were observed.
Timing of Late Quaternary Glaciations in the Western United States Based on the Age of Loess on the Eastern Snake River Plain, Idaho
- Steven L. Forman, Richard P. Smith, William R. Hackett, Julie A. Tullis, Paul A. McDaniel
-
- Journal:
- Quaternary Research / Volume 40 / Issue 1 / July 1993
- Published online by Cambridge University Press:
- 20 January 2017, pp. 30-37
-
- Article
- Export citation
-
The most viable sources for ubiquitous loess deposits on the eastern Snake River Plain, Idaho are aggraded river valleys, active alluvial fans, and fluctuating pluvial lake margins associated with regional late Pleistocene glaciation of the northern Rocky Mountains. Stratigraphic studies on the Idaho National Engineering Laboratory document two distinct loess deposits, separated by a well-developed paleosol, resting on basaltic lava. Baked sediments beneath this lava yielded thermoluminescence (TL) age estimates of 108,000 ± 13,000 and 101,000 ± 7000 yr, and baked organic matter gave radiocarbon ages of >32,000 yr B.P., consistent with an earlier K/Ar age for the flow of 95,000 ± 25,000 yr. The overlying two loess deposits yielded TL age estimates of 74,000 ± 6000 and 28,000 ± 3000 yr. The available geochronology indicates that the latest period of loess deposition commenced ca. 40,000 to 35,000 yr ago and ceased approximately 10,000 yr ago, which is generally coincident with the inferred timing of regional Pinedale glaciation and pluvial lake expansion. We estimate that the penultimate loess depositional episode dates between 80,000 and 60,000 yr ago, which is significantly younger than previous age estimates of 140,000 to 150,000 yr based on stratigraphic position. We speculate that this period of loess deposition may correlate with documented early to middle Wisconsinan glaciation and a high stand of pluvial lakes in the Basin and Range province.
Extensions to Maskell’s theory for blockage effects on bluff bodies in a closed wind tunnel
- J. E. Hackett, K. R. Cooper
-
- Journal:
- The Aeronautical Journal / Volume 105 / Issue 1050 / August 2001
- Published online by Cambridge University Press:
- 04 July 2016, pp. 409-418
-
- Article
- Export citation
-
Extensions to Maskell’s original correction method, developed over several years, are consolidated and designated ‘Maskell III’. The procedures were applied to dedicated tests on a family of flat-plate wing models in a small, low-speed wind tunnel at NRC. Test conditions included angles of attack from -10° to 110° and models of up to 16% of tunnel area. Off-centre tests were included with model-to-wall distances down to 0.72 chords. Corrected lift and drag data correlated well between models of different sizes and at different offsets from the tunnel centreline. Comparisons are made with corrections using the pressure-signature and two-variable methods, emphasising post-stall conditions. These showed that the ‘Maskell III’ procedures, which require minimal input, correlated as well as the other methods for most model sizes and positions in the tunnel.
A review of recent developments in flow control
- P. R. Ashill, J. L. Fulker, K. C. Hackett
-
- Journal:
- The Aeronautical Journal / Volume 109 / Issue 1095 / May 2005
- Published online by Cambridge University Press:
- 03 February 2016, pp. 205-232
-
- Article
- Export citation
-
This paper reviews and highlights recent developments of certain aspects of flow control concerned with reducing the drag of, and delaying flow separation on, wings and bodies over which the flow is turbulent. The study is restricted to devices that extend beyond the viscous sub-layer but are on a smaller scale than geometric features of the aircraft (e.g. wing chord).
The review is mainly concerned with developments within the UK, although significant developments in other countries are discussed.
The review discusses types of flow that need to be controlled, basic features of flow control devices and applications. It concludes with recommendations for future research.
The effect of soil tillage system on the nitrogen uptake, grain yield and nitrogen use efficiency of spring barley in a cool Atlantic climate
- J. BRENNAN, P. D. FORRISTAL, T. McCABE, R. HACKETT
-
- Journal:
- The Journal of Agricultural Science / Volume 153 / Issue 5 / July 2015
- Published online by Cambridge University Press:
- 30 July 2014, pp. 862-875
-
- Article
- Export citation
-
Field experiments were conducted between 2009 and 2011 in Ireland to compare the effects of soil tillage systems on the grain yield, nitrogen use efficiency (NUE) and nitrogen (N) uptake patterns of spring barley (Hordeum vulgare) in a cool Atlantic climate. The four tillage treatments comprised conventional tillage in spring (CT), reduced tillage in autumn (RT A), reduced tillage in spring (RT S) and reduced tillage in autumn and spring (RT A+S). Each tillage system was evaluated with five levels of fertilizer N (0, 75, 105, 135 and 165 kg N/ha). Grain yield varied between years but CT had a significantly higher mean yield over the three years than the RT systems. There was no significant difference between the three RT systems. Tillage system had no significant effect on the grain yield response to fertilizer N. As a result of the higher yields achieved, the CT system had a higher NUE than the RT systems at all N rates. There was no significant difference in NUE between the three RT systems. Conventional tillage had significantly higher nitrogen uptake efficiency (NUpE) than RT A and a significantly higher nitrogen utilization efficiency (NUtE) than all three RT systems. Crop N uptake followed a similar pattern each year. Large amounts of N were accumulated during the vegetative growth stages while N was lost after anthesis. Increased N rates had a positive effect on N uptake in the early growth stages but tended to promote N loss later in the season. The CT system had the highest N uptake in the initial growth stages but its rate of uptake diminished at a faster rate than the RT systems as the season progressed. Tillage system had an inconsistent effect on crop N content during the later growth stages. On the basis of these results it is concluded that the use of non-inversion tillage systems for spring barley establishment in a cool oceanic climate remains challenging and in certain conditions may result in a reduction in NUE and lower and more variable grain yields than conventional plough-based systems.
Contributors
-
- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
-
- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
-
- Chapter
- Export citation
The influence of a department-generated malnutrition universal screening tool (MUST) training package on malnutrition identification and management in care homes on the Wirral
- R. J. S. Costa, H. C. Hackett, M. Kent, A. M. Wigley
-
- Journal:
- Proceedings of the Nutrition Society / Volume 69 / Issue OCE2 / 2010
- Published online by Cambridge University Press:
- 01 April 2010, E157
-
- Article
-
- You have access Access
- HTML
- Export citation
Surface and species-specific antigens of Schistosoma haematobium
- C. Kelly, P. Hagan, M. Knight, J. Hodgson, A. J. G. Simpson, F. Hackett, H. A. Wilkins, S. R. Smithers
-
- Journal:
- Parasitology / Volume 95 / Issue 2 / October 1987
- Published online by Cambridge University Press:
- 06 April 2009, pp. 253-266
-
- Article
- Export citation
-
Of the surface antigens identified by radio-iodination, two-dimensional gel analyses showed no similarities between those of Schistosoma haematobium and Schistosoma mansoni, thus providing a basis for the species specificity of these antigens described previously (Simpson, Knight, Hagan, Hodgson, Wilkins & Smithers (1985) Parasitology 90, 499–508). The surface antigens of S. haematobium were glycosylated and comprised an acidic polypeptide of Mr 17000 as well as a complex set of polypeptides of approximate pI 6–7, which resolved in the Mr range 20000–30000. At least one of the lower Mr forms of this complex is also present in the adult worm. Limited cross-reaction was observed with S. mansoni infection sera and this may be due to a shared carbohydrate epitope. In contrast, extensive cross-reaction was observed using sera from mice immunized with S. bovis. This pattern parallels the species-specificity of vaccine-induced immunity. Extensive cross-reaction was also observed within cell-free translation products of m-RNA from adult worms of S. haematobium and S. mansoni by use of heterologous human infection sera. The few antigens which were species-specific may represent surface antigens.
Surface antigens of and cross-protection between two geographical isolates of Schistosoma mansoni
- F. Hackett, A. J. G. Simpson, P. Omer-Ali, S. R. Smithers
-
- Journal:
- Parasitology / Volume 94 / Issue 2 / April 1987
- Published online by Cambridge University Press:
- 06 April 2009, pp. 301-312
-
- Article
- Export citation
-
Two isolates of Schistosoma mansoni from Puerto Rico and Egypt were examined to determine if there were differences in surface antigens of the schistosomulum and to assess the ability of the two isolates to induce protection against one another in vivo. Immune mouse and human patient antisera recognized the same antigens on the schistosomulum surface of both isolates. However, mice immunized with schistosomula-released products from the Egyptian isolate recognized an additional antigen of Mr 13K on the Egyptian schistosomulum surface which was not present in the Puerto Rican isolate. In quantitative radioimmunoassay, sera from mice vaccinated with irradiated Egyptian cercariae bound more strongly to Egyptian schistosomula than to Puerto Rican parasites. Both isolates cross-protected against each other, but mice were less immune to challenge with Egyptian cercariae after being immunized with Puerto Rican irradiated cercariae. There was no difference in immunity to challenge when Egyptian irradiated cercariae were used to immunize. Although this evidence suggested some heterogeneity within the Egyptian isolate, cloned cercariae of the Egyptian isolate did not vary in their ability to cross-protect against each other. Furthermore, antisera from mice immunized with clones of Egyptian cercariae recognized the same schistosomulum surface antigens. The results reported here indicate that although there were small differences between the two isolates the major surface antigens are conserved.
Epitopes expressed on very low Mr Schistosoma mansoni adult tegumental antigens conform to a general pattern of life-cycle cross-reactivity
- A. J. G. Simpson, P. Hagan, F. Hackett, P. Omer Ali, S. R. Smithers
-
- Journal:
- Parasitology / Volume 100 / Issue 1 / February 1990
- Published online by Cambridge University Press:
- 06 April 2009, pp. 73-81
-
- Article
- Export citation
-
The relationship between antigens associated with the surface of newly transformed schistosomula of Schistosoma mansoni and the tegumental surface membrane of adult S. mansoni worms has been further explored. Immunoprecipitation of detergent-solubilized 125I-tegumental surface membrane antigens of adult S. mansoni with antibodies from mice vaccinated with highly irradiated S. mansoni cercariae revealed major antigens of Mr 32, 20, 15 and 8K. The Mr 32 and 20K antigens have been previously demonstrated to be antigenically and electrophoretically identical to major antigens on the schistosomulum surface. The Mr 15 and 8K antigens, on the other hand, have not been identified by the immunoprecipitation of 125I-schistosomulum surface antigens, although a distinct schistosomulum surface antigen of Mr 15K is precipitated by antibodies from mice vaccinated with highly irradiated cercariae. Nevertheless, it was shown that antibodies to the Mr 15 and 8K antigens were specifically absorbed from vaccinated mouse serum by intact, live schistosomula, demonstrating that the Mr 15 and 8K antigens are exposed on or released from the schistosomulum surface. In contrast, absorption of the antiserum with eggs failed to remove antibody against any of the four tegumental membrane antigens examined. The Mr 15 and 8K antigens were shown to be recognized via polypeptide epitopes and not periodate-sensitive carbohydrate epitopes, further emphasizing the similarity of these to the well-characterized Mr 32 and 20K tegumental surface membrane antigens. A general relationship between schistosomulum surface, adult tegumental membrane and egg antigens was demonstrated by ELISA, using antibodies raised against the three antigenic fractions. It was shown that both the egg and adult tegumental membrane antigens cross-react with the schistosomulum surface, but that the egg and adult membrane antigens exhibit very little, if any, mutual cross-reactivity. This antigen divergence possibly enables the host to dissociate pathological, anti-egg responses from potentially protective anti-membrane responses during the course of natural infection. It also suggests that adult membrane antigens could be used in an anti-schistosome vaccine without the possible complication of inducing pathological responses.
Bedtimes of 11 to 14-year-old children in north-east England
- A. J. Rugg-Gunn, A. F. Hackett, D. R. Appleton, J. E. Eastoe
-
- Journal:
- Journal of Biosocial Science / Volume 16 / Issue 2 / April 1984
- Published online by Cambridge University Press:
- 31 July 2008, pp. 291-297
-
- Article
- Export citation
-
As part of a longitudinal study of diet and dental caries, 405 Northumberland children initially aged 11–12 years recorded the time of going to bed on 3 consecutive days on 5 occasions over a 23-month period. The bedtimes were recorded in a personal diary and checked at private interview. Mean bedtime for the 212 females changed from 21 hr 44 min at age 11 years 7 months to 22 hr 11 min at age 13 years 3 months. Bedtime for the 193 males was, on average, 9 min later than that for the females. There was a consistent relation between bedtime and social class, with social class IV + V children going to bed, on average, 14 min later than social class I + II children. When the average age of the children was 13 years 3 months, 13% of them went to bed at or after 23.00 hr, and they were latest to bed on Saturday when their average bedtime was 22 hr 59 min.
19 - A single molecule method to quantify miRNA gene expression
- from IV - Detection and quantitation of microRNAs
-
- By Sonal Patel, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, Joanne Garver, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, Michael Gallo, Epic Therapeutics, Inc. 220 Norwood Park Norwood, MA 02062 USA, Maria Hackett, Novartis Institutes for Biomedical Research 250 Massachusetts Avenue Cambridge, MA 02139 USA, Stephen McLaughlin, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, Steven R. Gullans, RxGen, Inc. New Haven, CT USA, Mark Nadel, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, John Harris, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, Duncan Whitney, US Genomics, Inc. 12 Gill Street, Suite 4700 Woburn, MA 01801 USA, Lori A. Neely, Technology & Pre-Development Millipore Corp. 80 Ashby Rd. Bedford, MA 01730 USA
- Edited by Krishnarao Appasani
- Foreword by Sidney Altman, Victor R. Ambros
-
- Book:
- MicroRNAs
- Published online:
- 22 August 2009
- Print publication:
- 20 December 2007, pp 255-268
-
- Chapter
- Export citation
-
Summary
Introduction
Deemed the “breakthrough of the year” by Science magazine in 2002, research into the biology of small RNA regulation has grown exponentially in recent years; however, the field is relatively nascent in terms of identifying and characterizing the universe of miRNAs and their expression in various biological states. According to the miRNA registry (release 6.0, www.sanger.ac.uk/Software/Rfam/mirna/index.shtml); of the 319 predicted human miRNAs the expressions of 234 have been experimentally verified by Northern blot, cloning, or microarray. Further, the total number of miRNAs within a genome is unknown. Thus, sensitive, specific, quantitative, and rapid methods for measuring the expression levels of miRNAs would significantly advance the field.
The short 21 nucleotide nature of these molecules makes them difficult to study via conventional techniques. They are not easily amplified which makes miRNA microarrays and quantitative PCR technically challenging. Despite these challenges, several groups have undertaken miRNA microarray studies to quantify miRNA gene expression. Their approaches are similar in requiring up-front enrichment for small RNAs, reverse transcription, PCR amplification, labeling, and clean-up steps. While the arrays are superior at large scale screening they lack the ability to finely discriminate expression levels and are at best semi-quantitative. Theoretically the most sensitive technique to quantify miRNAs is reverse transcription RT-PCR (real time RT-PCR). However, this method is difficult in both assay (probe) design and execution. Tissue samples must be devoid of enzyme inhibitors to enable efficient reverse transcription and amplification steps (Tichopad et al., 2004).
Forum: American Religion and Class
- David G. Hackett, Laurie F. Maffly-Kipp, R. Laurence Moore, Leslie Woodcock Tentler
-
- Journal:
- Religion and American Culture / Volume 15 / Issue 1 / Winter 2005
- Published online by Cambridge University Press:
- 18 June 2018, pp. 1-29
- Print publication:
- Winter 2005
-
- Article
- Export citation
Multi-trait QTL mapping in barley using multivariate regression
- C. A. HACKETT, R. C. MEYER, W. T. B. THOMAS
-
- Journal:
- Genetical Research / Volume 77 / Issue 1 / February 2001
- Published online by Cambridge University Press:
- 05 April 2001, pp. 95-106
-
- Article
-
- You have access Access
- Export citation
-
Many studies of QTL locations record several different traits on the same population, but most analyses look at this information on a trait-by-trait basis. In this paper we show how the regression approach to QTL mapping of Haley & Knott (1992) may be extended to a multi-trait analysis via multivariate regression, easily programmed in statistical packages. A procedure for identifying QTL locations using forward selection and bootstrapping is proposed. The method is applied to examine the locations for QTLs for six yield characters (the number of fertile stems, the grain number of the main stem, the main stem grain weight, the single plant yield, the plot yield and the thousand grain weight) in a doubled haploid population of spring barley. Several chromosomal locations with effects on more than one trait are found. The method is also suitable for examining a single trait measured in different years or environments, and is used here to examine data on heading date, a highly heritable trait, and plot yield, a trait with moderate heritability and showing QTL–environment interactions.
Linkage analysis in tetraploid species: a simulation study
- C. A. HACKETT, J. E. BRADSHAW, R. C. MEYER, J. W. McNICOL, D. MILBOURNE, R. WAUGH
-
- Journal:
- Genetical Research / Volume 71 / Issue 2 / April 1998
- Published online by Cambridge University Press:
- 01 April 1998, pp. 143-153
-
- Article
-
- You have access Access
- Export citation
-
A simulation study was performed to investigate methods for mapping single-dose (simplex) and double-dose (duplex) markers, and for identification of homologous chromosomes in an autotetraploid species, and to see how the map accuracy depends on the population size. An initial population of 1000 individuals was simulated, with 30 simplex and 10 duplex markers, and recombination fractions and lod scores were calculated between all pairs of markers. These were used to test the feasibility of mapping the simplex and duplex markers simultaneously. Smaller populations, from 500 to 75 individuals, were then simulated, and the estimates of the pairwise recombination fractions and the derived maps were compared with the true map. It was found that the accuracy of the estimates depended strongly on the type of markers involved, with simplex–simplex coupling pairs being most reliable and simplex–simplex repulsion pairs and duplex–duplex pairs in any configuration but coupling being least reliable. Maps can be assembled using recombination fractions and lod scores from pairs of simplex–simplex markers (coupling and repulsion), duplex–simplex (coupling and repulsion) and duplex–duplex (coupling). The agreement between the map order and the true order was good, although the map distance was generally underestimated at small sample sizes.
Locating genotypes and genes for abiotic stress tolerance in barley: a strategy using maps, markers and the wild species
- B. P. FORSTER, J. R. RUSSELL, R. P. ELLIS, L. L. HANDLEY, D. ROBINSON, C. A. HACKETT, E. NEVO, R. WAUGH, D. C. GORDON, R. KEITH, W. POWELL
-
- Journal:
- The New Phytologist / Volume 137 / Issue 1 / September 1997
- Published online by Cambridge University Press:
- 01 September 1997, pp. 141-147
- Print publication:
- September 1997
-
- Article
- Export citation
-
This paper reviews the results of several years' study by a multidisciplinary team comprising geneticists, physiologists, ecologists and statisticians of abiotic stress tolerance in barley. The strategy involves genetic fingerprinting of wild barley lines (Hordeum spontaneum C. Koch) from a range of habitats and testing these for responses to abiotic stresses under controlled conditions. Multiple regression analysis is used to identify genetic markers associated with experimentally determined stress responses. These data are related to site-of-origin ecogeographic data and used to identify areas of useful wild variation. Markers associated with traits of interest can be mapped in genetic mapping populations, revealing areas of the barley genome carrying genes controlling stress responses. This paper highlights our work on associations of amplied fragment length polymorphisms with salt tolerance and describes some initial results of the use of SSRs in studying drought tolerance in barley.
Improvement of medication compliance in uncontrolled hypertension
- from Section 6 - Behavioural interventions in medicine
-
- By R. B. Haynes, McMaster University Medical Centre, D. L. Sackett, McMaster University Medical Centre, E. S. Gibson, McMaster University Medical Centre, D. W. Taylor, McMaster University Medical Centre, B. C. Hackett, McMaster University Medical Centre, R. S. Roberts, McMaster University Medical Centre, A. L. Johnson, McMaster University Medical Centre
- Edited by Andrew Steptoe, St George's Hospital Medical School, University of London, Jane Wardle, Imperial Cancer Research Fund, London
-
- Book:
- Psychosocial Processes and Health
- Published online:
- 05 August 2016
- Print publication:
- 24 November 1994, pp 457-467
-
- Chapter
- Export citation
-
Summary
Summary
38 hypertensive Canadian steelworkers who were neither compliant with medications nor at goal diastolic blood-pressure six months after starting treatment were allocated either to a control group or to an experimental group who were taught how to measure their own blood-pressures, asked to chart their home blood-pressures and pill taking, and taught how to tailor pill taking to their daily habits and rituals; these men were also seen fortnightly by a high-school graduate with no formal health professional training who reinforced the experimental manoeuvres and rewarded improvements in compliance and blood-pressure. Six months later, average compliance had fallen by 1.5% in the control group but rose 21.3% in the experimental group. Blood-pressures fell in 17 of 20 experimental patients (to goal in 6) and in 10 of 18 control patients (to goal in 2).
Introduction
The potential benefit of vigorous medical treatment for hypertension often remains out of reach, in part because the patient does not comply with treatment. We believe that this non-compliance is a major barrier to the effective control of hypertension and that our understanding of this phenomenon is primitive. In phase I of a trial of strategies for improving compliance we found that neither the mastery of facts about hypertension nor receiving care and follow-up at work in “company time” led to any improvement. We describe here the second phase of this trial in which the application of more behaviourally oriented strategies did lead to improvements in both compliance and blood-pressure control.
Methods
These have been described in detail elsewhere. Briefly, the examination of 5400 men at Dominion Foundries and Steel Company (over 95% of a random two-thirds sample of male employees) yielded 245 who had high blood-pressures (when sitting quietly on three separate days, a standard series of fifth-phase diastolic blood-pressure were ≥95 mm Hg), were free of remediable forms of hypertension, were taking no daily medications (70 men were on treatment and were therefore excluded), and had not been treated for hypertension in the preceding six months.
In phase I of this trial, men were randomly allocated into a factorial design in order to test strategies affecting either the convenience of their follow-up care or their knowledge about hypertension and its treatment.